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Oral ManifestationsQuestion 5/10

A 42-year-old man with HIV and a CD4 count of 514 cells/mm3 presents for evaluation of a cluster of painful blisters just below his lower lip (Figure 1). He has experienced multiple outbreaks of oral herpes in the past. Based on his past history and the appearance of the lesions, a diagnosis of orolabial herpes simplex virus (HSV) is made.

Which one of the following is appropriate for the treatment of recurrent oral herpes in persons with HIV?

Figure 1. Cluster of Vesicular Lesions Below Lower Lip
Source: photograph from David H. Spach, MD
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Question Last Updated
June 28th, 2026

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