Figure 1. Founder Virus and HIV Infection
This image shows multiple HIV particles approaching the mucosal surface, but only one virus sustaining replication. This virus, shown as the purple virion, is known as the 'founder virus'. Following the transmitter/founder virus infection, the initial local replication of HIV consists of a relatively homogenous population of virions.
Source: Keele BF, Giorgi EE, Salazar-Gonzalez JF, et al. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc Natl Acad Sci U S A. 2008;105:7552-7.Illustration: David H. Spach, MD
Figure 2. R5-Tropic HIV and Host Coreceptor Binding
With acute HIV, the type of HIV that is transmitted is almost always R5 HIV (as opposed to X4 HIV). The R5 HIV strains first attach to the host CD4 receptor and then bind to the CCR5 coreptor.
Illustration: David H. Spach, MD
Sign In or Register Progress Not Saved!
Since you are not signed in, your progress won't be saved.
Since you are not signed in, your progress won't be saved.
Question Last Updated
January 28th, 2025
January 28th, 2025
Steps to acquire a Certificate for this Lesson:
1
Answer Questions
Answer the board-review style questions
2
Answer Correctly
Score 80% on questions
3
Give Feedback
Complete survey
4