A 59-year-old man is seen in clinic for a follow-up visit. He was diagnosed with HIV in the mid-1990's and has received multiple antiretroviral regimens, including several older HIV protease inhibitors. He experienced two prior episodes of virologic failure while taking older, less effective antiretroviral regimens. Prior HIV genotypic drug-resistance assays showed the reverse transcriptase mutations M41L, K103N, M184V, G190A, L210W, and the protease mutation D30N (not a darunavir-associated mutation). He is currently taking a 5-drug regimen and the tentative plan is to simplify the antiretroviral regimen using boosted darunavir, dolutegravir, and doravirine.