A 58-year-old man who was diagnosed with HIV 10 years ago is seen in a clinic for a routine appointment. He has taken efavirenz-tenofovir DF-emtricitabine for approximately 8 years, and he consistently has an undetectable HIV RNA level. He has a significant past history of opiate use disorder and takes methadone 60 mg once daily via a methadone program. During the past 3 months, he has developed some depression, and the plan at this visit is to switch the antiretroviral regimen to bictegravir-tenofovir alafenamide-emtricitabine.