A 53-year-old woman has taken bictegravir-tenofovir alafenamide-emtricitabine for approximately 8 months and has gained 11 pounds. She wants to switch to a different regimen. She has never developed HIV drug resistance and consistently has HIV RNA levels less than 40 copies/mL. She is immune to hepatitis B virus (HBV). She also has gastroesophageal reflux and takes omeprazole 40 mg once daily, but she never takes antacids.