A 27-year-old man with HIV was recently diagnosed with cryptococcal meningitis. He received 2 weeks of induction therapy with intravenous liposomal amphotericin B and oral flucytosine, and he just completed 8 weeks of consolidation therapy with oral fluconazole 800 mg daily. He began taking antiretroviral therapy 5 weeks after starting the consolidation antifungal therapy. At this point, he has no neurologic symptoms and is tolerating antiretroviral therapy well.