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Opportunistic Infections: TreatmentQuestion 12/15

A 45-year-old man with HIV who is not taking antiretroviral medication presents to clinic for evaluation of visual floaters and blurry vision in his right eye for the past 2 days. An urgent ophthalmologic evaluation demonstrates a region of opacified, discolored retina involving the optic nerve head extending adjacent to the macula (Figure 1). He is diagnosed with sight-threatening cytomegalovirus (CMV) retinitis. The most recent laboratory studies obtained 6 months prior showed a CD4 count of 18 cells/mm3.

Which one of the following would be recommended as a preferred regimen for the initial treatment of CMV retinitis in this man?

This retinal photograph demonstrates an opacified, edematous retina (yellow) and hemorrhage (red); the retinitis involves the optic nerve head and extends adjacent to the macula along the retinal blood vessels.
Figure 1. Retinal Lesions in a Patient with AIDS
This retinal photograph demonstrates an opacified, edematous retina (yellow) and hemorrhage (red); the retinitis involves the optic nerve head and extends adjacent to the macula along the retinal blood vessels.
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Question Last Updated
May 8th, 2026

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