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Hepatitis B CoinfectionQuestion 10/10

A 26-year-old man with HIV has been taking dolutegravir-rilpivirine antiretroviral therapy for approximately 1 year with sustained suppression of HIV RNA levels; the most recent CD4 count was 512 cells/mm3. He has no other medical problems. He transfers his care to a new clinic, and on review of his immunization status, he states he has never received the hepatitis B vaccine. Laboratory studies are obtained that show:

  • Negative hepatitis B surface antigen (HBsAg)
  • Negative hepatitis B surface antibody (HBsAb)
  • Positive hepatitis B core antibody (anti-HBc total)

After reviewing the hepatitis B serologic studies, which one of the following should be recommended as the next step?

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Question Last Updated
May 8th, 2026

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