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HIV Preexposure Prophylaxis (PrEP)Question 10/10

A 22-year-old man who has sex with men presents for evaluation to start HIV preexposure prophylaxis (PrEP). He is interested in HIV PrEP but does not believe he would reliably take a pill every day. He states that he typically knows when he is likely to have sex, it does not occur more than a couple of times per month, and he says he can follow a schedule for taking pills before and after sex.

Which one of the following is the recommended dosing schedule for “on-demand” or “2-1-1” tenofovir DF-emtricitabine for HIV PrEP?

Figure 1 (Image Series). On Demand (2-1-1) Oral HIV Preexposure Prophylaxis
Illustration: David H. Spach, MD
Note: if sexual activity continues for multiple consecutive days, the every 24-hour dosing continues.
Figure 1B. On Demand (2-1-1) Oral HIV Preexposure Prophylaxis with Continued Sexual Activity
Note: if sexual activity continues for multiple consecutive days, the every 24-hour dosing continues.
Illustration: David H. Spach, MD
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Question Last Updated
July 6th, 2026

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