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HIV Clinical Care Question Bank

Initial EvaluationQuestion 7/10

A 31-year-old man is newly diagnosed with HIV and presents to a clinic 3 days later for initial evaluation. The pre-visit initial laboratory studies show a CD4 count of 573 cells/mm3 and an HIV RNA of 68,730 copies/mL. He has not received HIV preexposure prophylaxis (PrEP).

Which one of the following would you recommend regarding HIV drug-resistance testing?

In the absence of antiretroviral selective pressure, some of the transmitted drug-resistant HIV may back mutate to wild-type HIV or simply be overpopulated by wild-type HIV. In this situation, the ability to detect these drug-resistant mutations on a standard genotype will diminish over time.
Figure 1. Reversion of Transmitted Drug-Resistant HIV in the Absence of Antiretroviral Therapy
In the absence of antiretroviral selective pressure, some of the transmitted drug-resistant HIV may back mutate to wild-type HIV or simply be overpopulated by wild-type HIV. In this situation, the ability to detect these drug-resistant mutations on a standard genotype will diminish over time.
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Question Last Updated
January 28th, 2025

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