Antiretroviral Therapy

Self-StudyAntiretroviral Therapy

Antiretroviral Therapy
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Antiretroviral Therapy

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Core Competencies

Antiretroviral Medications and Initial Therapy

Topic
Learning Objectives
Background
HIV Life Cycle and Antiretroviral Drug Targets
When to Initiate Antiretroviral Therapy
Antiretroviral Regimens for Initial Therapy
Choosing a Specific Antiretroviral Regimen
Monitoring Response to Antiretroviral Therapy
Poor CD4 Response to Antiretroviral Therapy
Discontinuation or Treatment Interruption
Summary Points

Adverse Effects of Antiretroviral Medications

Topic
Learning Objectives
Introduction
Entry Inhibitors
Integrase Strand Transfer Inhibitors
Nucleoside Reverse Transcriptase Inhibitors
Non-Nucleoside Reverse Transcriptase Inhibitors
Pharmacologic Boosters
Protease Inhibitors
Capsid Inhibitors
Summary Points

Drug Interactions with Antiretroviral Medications

Topic
Learning Objectives
Overview
Acid Suppressive Therapy and Supplements
Antimycobacterials
Cardiovascular Medications
Corticosteroids
Hepatitis C Treatments
HMG-CoA Reductase Inhibitors (Statins)
Mental Health Medications
Opioid Agonist Therapy
Oral Anticoagulants and Antiplatelet Therapy
Phosphodiesterase Type 5 (PDE5) Inhibitors
Miscellaneous Interactions
Summary Points

Switching or Simplifying Antiretroviral Therapy

Topic
Learning Objectives
Principles of Switching or Simplifying Antiretroviral Therapy
Switching to an Integrase Strand Transfer Inhibitor
Switching to a Non-Nucleoside Reverse Transcriptase Inhibitor
Within-Class Nucleoside Reverse Transcriptase Inhibitor Switches
Simplifying Therapy to An Oral Two-Drug Regimen
Simplifying Therapy to Injectable Cabotegravir and Rilpivirine
Simplifying Maintenance Therapy to Monotherapy
Summary Points

Evaluation and Management of Virologic Failure

Topic
Learning Objectives
Introduction
Definition of Terms Related to Virologic Responses
Causes of Virologic Failure
Approach to Detectable HIV RNA Levels
HIV Drug Resistance Assays
Indications for HIV Drug-Resistance Testing
Interpretation of Drug-Resistance Assays
Nucleoside Reverse Transcriptase Inhibitor Resistance
Non-Nucleoside Reverse Transcriptase Inhibitor Resistance
Integrase Strand Transfer Inhibitor Resistance
Protease Inhibitor Resistance
Entry Inhibitor Resistance
Capsid Inhibitors
General Approach to Management of Virologic Failure
Summary Points

Self-Study Module Progress Tracker - 3rd Edition

Lesson 1Antiretroviral Medications and Initial Therapy
  • List the major classes of antiretroviral medications
  • Explain the mechanism of action with each class of antiretroviral medications
  • Summarize evidence supporting antiretroviral treatment of all persons with HIV
  • Describe recommended antiretroviral regimens for treatment-naïve individuals and discuss factors to consider when selecting an initial regimen
  • Discuss recommended laboratory studies to obtain at baseline and while monitoring response to therapy
Lesson 2Adverse Effects of Antiretroviral Medications
  • Summarize common adverse effects associated with antiretroviral medications
  • Identify serious adverse effects caused by antiretroviral therapy
  • List appropriate baseline laboratory studies to perform when starting antiretroviral therapy
  • Discuss frequency of types of laboratory tests for monitoring persons taking antiretroviral therapy
  • Explain management strategies for antiretroviral-related adverse effects
Lesson 3Drug Interactions with Antiretroviral Medications
  • Explain the difference between pharmacokinetics and pharmacodynamics
  • Access resources for checking drug interactions that involve antiretroviral medications
  • Identify commonly used antiretroviral medications that often cause significant drug interactions
  • Discuss how antiretroviral medications can increase or decrease levels of some medications when coadministered
  • Describe potential drug interactions between antiretroviral medications and medications commonly used to treat comorbid conditions
Lesson 4Switching or Simplifying Antiretroviral Therapy
  • Discuss the rationale for switching or simplifying antiretroviral therapy
  • Describe common situations to consider for simplifying antiretroviral therapy
  • Explain why some antiretroviral medications generally warrant a switch to a newer agent
  • List the two-drug regimens that have been FDA-approved for maintenance antiretroviral therapy
  • Summarize key findings with studies involving a switch to an integrase strand transfer inhibitor
Lesson 5Evaluation and Management of Virologic Failure
  • Describe the management of intermittent and persistently detectable HIV RNA levels in persons receiving antiretroviral therapy
  • Discuss the indications for and types of resistance testing for patients with virologic failure
  • Utilize an HIV resistance database tool to assist in the optimal selection of regimens in persons with HIV drug resistance
  • Summarize concepts of resistance with different antiretroviral drug classes
  • Explain key considerations when selecting a salvage antiretroviral regimen in persons with virologic failure
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CE Quiz 
 
 
 
 

Self-Study Module Progress Tracker - 2nd Edition

2nd Edition. There is a newer edition of this Self-Study Module.
Lesson 1Antiretroviral Medications and Initial Therapy
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • List the major classes of antiretroviral medications
  • Explain the mechanism of action with each class of antiretroviral medications
  • Summarize evidence supporting antiretroviral treatment of all persons with HIV
  • Describe recommended antiretroviral regimens for treatment-naïve individuals and discuss factors to consider when selecting an initial regimen
  • Discuss recommended laboratory studies to obtain at baseline and while monitoring response to therapy
Lesson 2Adverse Effects of Antiretroviral Medications
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • Summarize common adverse effects associated with antiretroviral medications
  • Identify serious adverse effects caused by antiretroviral therapy
  • List appropriate baseline laboratory studies to perform when starting antiretroviral therapy
  • Discuss frequency of types of laboratory tests for monitoring persons taking antiretroviral therapy
  • Explain management strategies for antiretroviral-related adverse effects
Lesson 3Drug Interactions with Antiretroviral Medications
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • Explain the difference between pharmacokinetics and pharmacodynamics
  • Access resources for checking drug interactions that involve antiretroviral medications
  • Identify commonly used antiretroviral medications that often cause significant drug interactions
  • Discuss how some antiretroviral increase levels of medications and others decrease levels of medications
  • Describe several drug interactions involving antiretroviral medications and common therapeutic classes of drugs used to treat comorbid conditions
Lesson 4Switching or Simplifying Antiretroviral Therapy
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • Discuss the rationale for switching or simplifying antiretroviral therapy
  • Describe common situations to consider for simplifying antiretroviral therapy
  • Explain why some antiretroviral medications generally warrant a switch to a newer agent
  • List the two-drug regimens that have been FDA-approved for maintenance antiretroviral therapy
  • Summarize key findings with studies involving a switch to an integrase strand transfer inhibitor
Lesson 5Evaluation and Management of Virologic Failure
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • Describe the management of intermittent and persistently detectable HIV RNA levels in persons receiving antiretroviral therapy
  • Discuss the indications for and types of resistance testing for patients with virologic failure
  • Utilize an HIV resistance database tool to assist in the optimal selection of regimens in persons with HIV drug resistance
  • Summarize concepts of resistance with different antiretroviral drug classes
  • Explain key considerations when selecting a salvage antiretroviral regimen in persons with virologic failure
Topic 1 
 
 
 
 
Topic 2 
 
 
 
 
Topic 3 
 
 
 
 
Topic 4 
 
 
 
 
Topic 5 
 
 
 
 
Topic 6 
 
 
 
 
Topic 7 
 
 
 
 
Topic 8 
 
 
 
Topic 9 
 
 
Topic 10 
 
 
Topic 11 
 
Topic 12 
 
Topic 13 
 
Topic 14 
 
Topic 15 
CE Quiz

Self-Study Module Progress Tracker - 1st Edition

1st Edition. There is a newer edition of this Self-Study Module.
Lesson 1Antiretroviral Medications and Initial Therapy
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • List the major classes of antiretroviral medications
  • Explain the mechanism of action with each class of antiretroviral medications
  • Summarize evidence supporting antiretroviral treatment of all persons with HIV
  • Describe recommended antiretroviral regimens for treatment-naïve individuals and discuss factors to consider when selecting an initial regimen
  • Discuss recommended laboratory studies to obtain at baseline and while monitoring response to therapy
Lesson 2Adverse Effects of Antiretroviral Medications
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • Summarize common adverse effects associated with antiretroviral medications
  • Identify serious adverse effects caused by antiretroviral therapy
  • List appropriate baseline laboratory studies to perform when starting antiretroviral therapy
  • Discuss frequency of types of laboratory tests for monitoring persons taking antiretroviral therapy
  • Explain management strategies for antiretroviral-related adverse effects
Lesson 3Drug Interactions with Antiretroviral Medications
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • Explain the difference between pharmacokinetics and pharmacodynamics
  • Access resources for checking drug interactions that involve antiretroviral medications
  • Identify commonly used antiretroviral medications that often cause significant drug interactions
  • Discuss how some antiretroviral increase levels of medications and others decrease levels of medications
  • Describe several drug interactions involving antiretroviral medications and common therapeutic classes of drugs used to treat comorbid conditions
Lesson 4Switching or Simplifying Antiretroviral Therapy
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • Discuss the rationale for switching or simplifying antiretroviral therapy
  • Describe common situations to consider for simplifying antiretroviral therapy
  • Explain why some antiretroviral medications generally warrant a switch to a newer agent
  • List the two-drug regimens that have been FDA-approved for maintenance antiretroviral therapy
  • Summarize key findings with studies involving a switch to an integrase strand transfer inhibitor
Lesson 5Evaluation and Management of Virologic Failure
2nd Edition. There is a newer edition of this Lesson. This is your progress from the previous edition (2nd).
  • Describe the management of intermittent and persistently detectable HIV RNA levels in persons receiving antiretroviral therapy
  • Discuss the indications for and types of resistance testing for patients with virologic failure
  • Utilize an HIV resistance database tool to assist in the optimal selection of regimens in persons with HIV drug resistance
  • Summarize concepts of resistance with different antiretroviral drug classes
  • Explain key considerations when selecting a salvage antiretroviral regimen in persons with virologic failure
Topic 1 
 
 
 
 
Topic 2 
 
 
 
 
Topic 3 
 
 
 
 
Topic 4 
 
 
 
 
Topic 5 
 
 
 
 
Topic 6 
 
 
 
 
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CE Quiz

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