Common TitleASTRAL-5
Official Title Sofosbuvir and Velpatasvir for the Treatment of HCV in Patients Coinfected with HIV-1: an Open-Label, Phase 3 Study
Phase Phase III
ClinicalTrials.gov NCT02480712
Funding
IndustryGilead Sciences
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- 13-valent pneumococcal conjugate vaccine Prevnar 13( trials)
- 15-valent pneumococcal conjugate vaccine Vaxneuvance( trials)
- 20-valent pneumococcal conjugate vaccine Prevnar 20( trials)
- 21-valent pneumococcal conjugate vaccine Capvaxive( trials)
- 23-valent pneumococcal polysaccharide vaccine Pneumovax 23( trials)
- 2vHPV Cervarix( trials)
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- 7-valent conjugate pneumococcal vaccine Prevnar( trials)
- 9vHPV Gardasil 9( trials)
- Acamprosate Campral( trials)
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- Acetazolamide Diamox( trials)
- Acyclovir Zovirax( trials)
- Adalimumab Humira( trials)
- Adjuvanted inactivated influenza vaccine Fluad( trials)
- Albendazole Albenza( trials)
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- Alirocumab Praluent( trials)
- Alitretinoin Panretin( trials)
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- Amikacin Amikin( trials)
- Amiodarone Cordarone( trials)
- Amlexanox Aphthasol( trials)
- Amlodipine Norvasc( trials)
- Amoxicillin-clavulanate Augmentin( trials)
- Amphotericin B deoxycholate Amphocin, Fungizone( trials)
- Amphotericin B lipid complex Abelcet( trials)
- Anidulafungin Eraxis( trials)
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- Atenolol Tenormin( trials)
- Atorvastatin Lipitor( trials)
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- Avanafil Stendra( trials)
- Azelastine (nasal spray) Astelin, Astepro( trials)
- Azelastine-Fluticasone (nasal spray) Dymista( trials)
- Azithromycin Zithromax( trials)
- Baclofen Kemstro, Lioresal( trials)
- Beclomethasone (inhaled) Beclovent, Qvar( trials)
- Beclomethasone (nasal spray) Beconase( trials)
- Benazepril Lotensin( trials)
- Bezafibrate Bezalip( trials)
Bictegravir-Tenofovir alafenamide-Emtricitabine Biktarvy(8 trials)- Bioadherent oral rinse gel Gelclair( trials)
- Brincidofovir Tembexa( trials)
- Budesonide (inhaled) Pulmicort( trials)
- Budesonide (nasal spray) Rhinocort( trials)
- Buprenorphine Subutex( trials)
- Buprenorphine implant Probuphine( trials)
- Buprenorphine-Naloxone Suboxone( trials)
- Bupropion Wellbutrin( trials)
- Buspirone Buspar( trials)
- Cabotegravir Apretude(6 trials)
- Calcium hydroxylapatite Radiesse, Coaptite( trials)
- Candesartan Atacand( trials)
- Carbamazepine Equetro, Tegretol( trials)
- Caspofungin Cancidas( trials)
- Cefixime Suprax( trials)
- Ceftriaxone Rocephin( trials)
- Cephalexin Keflex( trials)
- Cetirizine Zyrtec( trials)
- Chlorhexidine gluconate (oral rinse) Paroex, Peridex, Periogard( trials)
- Cholestyramine Questran( trials)
- Cidofovir Vistide( trials)
- Ciprofloxacin Cipro( trials)
- Citalopram Celexa( trials)
- Clarithromycin Biaxin( trials)
- Clindamycin Cleocin( trials)
- Clonazepam Klonopin( trials)
- Clopidogrel Plavix( trials)
- Clotrimazole lozenges (troche) Mycelex( trials)
- CMV immune globulin Cytogam( trials)
- Colestipol Colestid( trials)
- Copper-containing intrauterine device ParaGard( trials)
- Cyclosporine Gengraf, Neoral, Sandimmune( trials)
- Cytarabine Cytosar-U, Tarabine PFS( trials)
- Cytomegalovirus immune globulin intravenous Cytogam( trials)
- Dabigatran Pradaxa( trials)
- Daclatasvir Daklinza(1 trial)
- Dapivirine ring (2 trials)
- Dapsone Avlosulfon( trials)
- Darbepoetin Aranesp( trials)
Darunavir-Cobicistat-Tenofovir alafenamide-Emtricitabine Symtuza(4 trials)- Dasabuvir-Ombitasvir-Paritaprevir-Ritonavir Viekira XR( trials)
- Denosumab Prolia, Xgeva( trials)
- Depot-medroxyprogesterone acetate Depo-Provera( trials)
- Diazepam Valium( trials)
- Digoxin Lanoxin( trials)
- Diltiazem Cardiazem( trials)
- Diphenhydramine Benadryl( trials)
- Disulfiram Antabuse( trials)
- Dofetilide Tikosyn( trials)
Dolutegravir Tivicay(15 trials)
Dolutegravir-Abacavir-Lamivudine Triumeq(4 trials)
Dolutegravir-Lamivudine Dovato(8 trials)
Dolutegravir-Rilpivirine Juluca(2 trials)
Doravirine Pifeltro(5 trials)
Doravirine-Tenofovir DF-Lamivudine Delstrigo(4 trials)- Doxazosin Cardura( trials)
- Doxepin Sinequan( trials)
- Doxycycline Doryx, Monodox, Vibramycin( trials)
- Eculizumab Soliris( trials)
- Edoxaban Savaysa( trials)
- Edoxoban Savaysa( trials)
Efavirenz Sustiva(17 trials)
Efavirenz-Tenofovir DF-Emtricitabine Atripla(10 trials)- Efavirenz-Tenofovir DF-Emtricitabine Atripla( trials)
- Efavirenz-Tenofovir DF-Lamivudine Symfi and Symfi Lo( trials)
- Elbasvir-Grazoprevir Zepatier(1 trial)
Elvitegravir-Cobicistat-Tenofovir alafenamide-Emtricitabine Genvoya(5 trials)
Elvitegravir-Cobicistat-Tenofovir DF-Emtricitabine Stribild(5 trials)- Elvitegravir-Cobicistat-Tenofovir DF-Emtricitabine Stribild( trials)
- Enalapril Vasotec( trials)
- Entecavir Baraclude( trials)
- Epoetin alfa Epogen, Procrit( trials)
- Escitalopram Lexapro( trials)
- Esomeprazole Nexium( trials)
- Etanercept Enbrel( trials)
- Ethambutol Myambutol( trials)
- Etonogestrel implant Nexplanon( trials)
Etravirine Intelence(3 trials)- Evolocumab Repatha( trials)
- Extended-release injectable naltrexone Vivitrol( trials)
- Extended-release injection buprenorphine Sublocade( trials)
- Ezetimibe Zetia( trials)
- Ezetimibe-atorvastatin Liptruzet( trials)
- Ezetimibe-simvastatin Vytorin( trials)
- Famciclovir Famvir( trials)
- Famotidine Pepcid( trials)
- Felodipine Plendil( trials)
- Fenofibrate Tricor( trials)
- Filgrastim Neupogen( trials)
- Filgrastim-sndz Zarxio( trials)
- Flecainide Tambocor( trials)
- Fluconazole Diflucan( trials)
- Flucytosine Ancobon( trials)
- Flunitrazepam Rohypnol( trials)
- Fluocinonide Lidex( trials)
- Fluticasone (inhaled) Flovent( trials)
- Fluticasone (nasal spray) Flonase( trials)
- Foscarnet Foscavir( trials)
Fostemsavir Rukobia(2 trials)- Furosemide Lasix( trials)
- Gabapentin Neurontin( trials)
- Ganciclovir Cytovene( trials)
- Gemfibrozil Gemcor, Lopid( trials)
- Gemifloxacin Factive( trials)
- Glecaprevir-Pibrentasvir Mavyret(1 trial)
- Glipizide Glucotrol( trials)
- Glyburide Diabeta, Glynase( trials)
- Granisetron Kytril( trials)
- HepB-CpG Heplisav-B( trials)
- High-dose inactivated influenza vaccine Fluzone High-Dose( trials)
- Human Papillomavirus 2-valent vaccine Cervarix( trials)
- Human papillomavirus 4-valent vaccine Gardasil( trials)
- Human papillomavirus 9-valent vaccine Gardasil 9( trials)
- Hyaluronic acid Restylane, Perlane, Prevelle SILK, Juvederm( trials)
- Hydrocholorothiazide Esidrix, Hydrodiuril, Microzide, Oretic, Zide( trials)
- Hydroxyzine Vistaril, Atarax( trials)
Ibalizumab Trogarzo(2 trials)- Ibuprofen Motrin, Advil( trials)
- Imiquimod 3.75% cream Zyclara( trials)
- Imiquimod 5% cream Aldara( trials)
- Indomethacin Indocid, Indocin( trials)
- Infliximab Remicade( trials)
- Infliximab Remicade( trials)
- Inhaled pentamidine Nebupent( trials)
- Injectable cabotegravir and Rilpivirine Cabenuva(9 trials)
- Injectable testosterone Depo-Testosterone, Xyosted, Multiple Generics( trials)
- Insulin glargine Lantus, Toujeo( trials)
- Insulin lispro Humalog( trials)
- Isavuconazole Cresemba( trials)
- Itraconazole Sporanox( trials)
- Ivermectin Stromectol( trials)
- Ketoconazole Nizoral( trials)
- Labetalol Normodyne, Trandate( trials)
- Lamotrigine Lamictal( trials)
- Lansoprazole Prevacid( trials)
- Ledipasvir-Sofosbuvir Harvoni(1 trial)
- Lenacapavir (2 trials)
- Leucovorin Wellcovorin( trials)
- Levetiracetam Keppra( trials)
- Levofloxacin Levaquin( trials)
- Levonorgestrel-releasing intrauterine device Mirena, Liletta, Kyleena, Skyla( trials)
- Linezolid Zyvox( trials)
- Liposomal amphotericin B Ambisome( trials)
- Liposomal daunorubicin DaunoXome( trials)
- Liposomal doxorubicin Doxil( trials)
- Lisinopril Prinivil, Zestril( trials)
- Live attenuated influenza vaccine Flumist( trials)
- Long-Acting Testosterone Undecanoate Injection Aveed( trials)
- long-acting testosterone undecanoate injection Aveed( trials)
- Loratidine Claritin( trials)
- Lorazepam Ativan( trials)
- Losartan Cozar( trials)
- Lovastatin Mevacor( trials)
- Lurasidone Latuda( trials)
- Mannitol Osmitrol( trials)
Maraviroc Selzentry(5 trials)- Measles-Mumps-Rubella vaccine M-M-R II( trials)
- Measles-Mumps-Rubella-Varicella vaccine ProQuad( trials)
- MenACWY-CRM Menveo( trials)
- MenACWY-D Menactra( trials)
- MenACWY-TT MenQuadfi( trials)
- MenB-4C Bexsero( trials)
- MenB-FHbp Trumenba( trials)
- Meningococcal conjugate vaccine-CRM Menveo( trials)
- Meningococcal conjugate vaccine-D Menactra( trials)
- Meningococcal group B vaccine-4C Bexsero( trials)
- Meningococcal group B vaccine-FHbp Trumemba( trials)
- Meningococcal polysaccharide vaccine Menomune( trials)
- Metformin Fortamet, Glumetza, Glucophage( trials)
- Methadone Dolophine, Methadose( trials)
- Methylergonovine Methergine( trials)
- Methylphenidate Aptensio, Concerta, Metadate, Methylin, Quillichew( trials)
- Methylprednisolone Medrol( trials)
- Metoclopramide Reglan( trials)
- Metronidazole Flagyl( trials)
- Metronidazole gel Metrogel( trials)
- Micafungin Mycamine( trials)
- Miconazole buccal tablets Oravig( trials)
- Midazolam Versed( trials)
- Mirtazapine Remeron( trials)
- Misoprostol Cytotec( trials)
- Modafinil Provigil( trials)
- Moderna Spikevax( trials)
- Mometasone (inhaled) Asmanex( trials)
- Mometasone (nasal spray) Nasonex( trials)
- Moxifloxacin Avelox( trials)
- Nadolol Corgard( trials)
- Naloxone Narcan( trials)
- Naltrexone Decade, ReVia( trials)
- Naproxen Aleve, Anaprox, Naprosyn( trials)
- Nifedipine Adalat, Procardia( trials)
- Nitazoxanide Alinia( trials)
- Nitrofurantoin Furadantin, Macrobid, Macrodantin( trials)
- Nystatin lozenges (pastille) Mycostatin( trials)
- Nystatin suspension Nilstat( trials)
- Odansetron Zofran( trials)
- Ofloxacin Floxin( trials)
- Olanzapine Zyprexa( trials)
- Ombitasvir-Paritaprevir-Ritonavir Technivie( trials)
- Omeprazole Prilosec( trials)
- Oral Testosterone Decanoante Jatenzo( trials)
- Oxazepam Serax( trials)
- Oxcarbazepine Trileptal( trials)
- Oxymorphone Opana( trials)
- Oxytocin Pitocin( trials)
- Paclitaxel Taxol, Onxal( trials)
- Pantoprazole Protonix( trials)
- Paromomycin Humatin( trials)
- Paroxetine Paxil( trials)
- PCV13 Prevnar 13( trials)
- PCV7 Prevnar( trials)
- Peginterferon alfa-2a Pegasys( trials)
- Peginterferon alfa-2b Pegintron( trials)
- Pembrolizumab Keytruda( trials)
- Penciclovir cream Denavir( trials)
- Pentamidine Pentam( trials)
- Permethrin 5% cream Elimite, Nix( trials)
- Perphenazine Trilafon( trials)
- Pfizer-BioNTech Comirnaty( trials)
- Phenobarbital Luminal, Solfoton( trials)
- Phenytoin Dilantin( trials)
- Pitavastatin Livalo( trials)
- Podofilox 0.5% solution or gel Condylox( trials)
- Poly-L-lactic acid Sculptra( trials)
- Polyacrylamide gel Aquamid, Eutrophill( trials)
- Polyalkylimide gel Bio-Alcamid( trials)
- Polymethylmethacrylate Metacrill, Artefill( trials)
- Posaconazole Noxafil( trials)
- PPSV23 Pneumovax 23( trials)
- Prasugrel Effient( trials)
- Pravastatin Pravachol( trials)
- Pregabalin Lyrica( trials)
- Prothrombin Complex Concentrate Kcentra( trials)
- Pyrimethamine Daraprim( trials)
- Quetiapine Seroquel( trials)
- Rabeprazole AcipHex( trials)
Raltegravir Isentress(10 trials)- Ramipril Altace( trials)
- Ravulizumab Ultomiris( trials)
- Recombinant influenza vaccine FluBlok( trials)
- Recombinant zoster vaccine Shingrex( trials)
- Reserpine Serpalan, Serpasil( trials)
- Ribavirin Copegus, Rebetol, Ribasphere( trials)
- Rifabutin Mycobutin( trials)
- Rifampin Rifadin, Rimactane( trials)
- Rifapentine Priftin( trials)
Rilpivirine Edurant(5 trials)
Rilpivirine-Tenofovir alafenamide-Emtricitabine Odefsey(2 trials)
Rilpivirine-Tenofovir DF-Emtricitabine Complera(8 trials)- Rilpivirine-Tenofovir DF-Emtricitabine Complera( trials)
- Risedronate Actonel, Atelvia( trials)
- Risperidone Risperdal( trials)
- Rituximab Rituxan, MabThera( trials)
- Rivaroxaban Xarelto( trials)
- Rosuvastatin Crestor( trials)
- Salmeterol Serevent( trials)
- Secnidazole Solesec( trials)
- Sertraline Zoloft( trials)
- Sildenafil Viagra( trials)
- Silicone oil Silikon 1000, VitreSil( trials)
- Simeprevir Olysio(1 trial)
- Simvastatin Zocor( trials)
- Sinecatechins 15% ointment Veregen( trials)
- Sitagliptin Januvia( trials)
- Sofosbuvir Sovaldi(2 trials)
- Sofosbuvir-Velpatasvir Epclusa(1 trial)
- Sofosbuvir-Velpatasvir-Voxilaprevir Vosevi( trials)
- Sotalol Betapace( trials)
- SUBA Itraconazole Tolsura( trials)
- Sucralfate Carafate( trials)
- Sumatriptan Imitrex( trials)
- Sustained-release bupropion Zyban( trials)
- Tadalafil Cialis( trials)
- Tecovirimat TPOXX( trials)
- Telbivudine Tyzeka( trials)
- Temazepam Restoril( trials)
Tenofovir alafenamide-Emtricitabine Descovy(17 trials)
Tenofovir DF-Emtricitabine Truvada and Multiple Generics(25 trials)- Tenofovir DF-Lamivudine Cimduo( trials)
- Terbinafine Lamisil( trials)
- Testosterone gel Androgel, Axiron, Fortesta, Testim, Vogelxo, Multi( trials)
- Testosterone pellets Testopel( trials)
- Testosterone transdermal patch Androderm and Multiple Generics( trials)
- Thalidomide Thalomid( trials)
- Thioreidazine Mellaril( trials)
- Ticagrelor Brilinta( trials)
- Tinidazole Tindamax( trials)
- Topiramate Topamax( trials)
- Transient elastography FibroScan( trials)
- Trazodone Desyrel, Molinpaxin, Oleptro( trials)
- Triamcinolone (inhaled) Azmacort( trials)
- Triamcinolone (nasal spray) Allernaze, Nasacort( trials)
- Triamcinolone acetonide 0.1% dental paste Kenalog in Orabase( trials)
- Triazolam Halcion( trials)
- Trifluridine Viroptic( trials)
- Trimethoprim Primsol( trials)
- Trimethoprim-sulfamethoxazole Bactrim, Septra( trials)
- Valacyclovir Valtrex( trials)
- Valganciclovir Valcyte( trials)
- Valsartan Diovan( trials)
- Vardenafil Levitra( trials)
- Varenicline Chantix( trials)
- Varicella vaccine Varivax( trials)
- Varicella-zoster immune globulin VariZIG( trials)
- Verapamil Calan, Covera, Veralan( trials)
- Vinblastine Velbe( trials)
- Voriconazole Vfend( trials)
- Warfarin Coumadin( trials)
- Zoledronic acid Reclast, Zometa( trials)
- Zolpidem Ambien( trials)
- Zoster vaccine live Zostavax( trials)