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HIV Biology and Mechanism of Action of Antiretroviral Medications

HIV Capsid Inhibitors: Mechanism of Action

July 17, 2024
Dr. David Spach discusses HIV capsid inhibitors, a new antiviral medication class. Using unique illustrations, he first reviews basic concepts related to the normal structure and function of the HIV capsid before exploring the highly unique multistage mechanism of action that includes inhibition of capsid nuclear import, inhibition of capsid uncoating, and inhibition of capsid assembly. He also talks about the initiation and maintenance dosing of lenacapavir — the first and only FDA-approved capsid inhibitor as of July 2024.
 PDF  Powerpoint
David H. Spach, MD
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington
Disclosures
Disclosures for David H. Spach, MD
None

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