Prevention of HIV

Self-StudyPrevention of HIV

Apply Evidence-Based Recommendations for the Prevention of HIV Transmission
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Lesson 3. Occupational Postexposure Prophylaxis

Apply Evidence-Based Recommendations for the Prevention of HIV Transmission

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Occupational Postexposure Prophylaxis Overview

About this Lesson

Last Updated: December 1st, 2025

CNE/CME Continuing Education

This lesson qualifies for:
  • 1 CME AMA PRA Category 1 Credit™, or
  • 1 CNE contact hour and 1 CE contact hour (qualifies for pharmacology CE for advanced practice nurses)

CNE and CME Origination: July 1st, 2017
CNE and CME Review: September 1st, 2023
CNE and CME Expiration: August 31st, 2026 (3rd Edition)

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3rd Edition

This is a substantial revision of the original Lesson. The previous edition was titled Occupational Postexposure Prophylaxis and available until September 1st, 2023.

Learning Objectives

  • Discuss risk for occupational acquisition of HIV with a needlestick injury
  • State the rationale for using occupational HIV postexposure prophylaxis (PEP)
  • Describe current indications for the use of occupational HIV PEP, including strategies for risk assessment following an occupational exposure
  • Summarize recommended antiretroviral therapy regimens and duration of therapy for occupational HIV PEP
  • List recommended clinical and laboratory monitoring following occupational exposure to HIV

Lesson Contributors

Authors

David H. Spach, MD
David H. Spach, MD
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington
Disclosures:
None
Aley G. Kalapila, MD, PhD
Aley G. Kalapila, MD, PhD
Professor of Medicine
Division of Infectious Diseases
Emory University School of Medicine
Grady Health System
Disclosures:
None

Reviewers

Jehan Z. Budak, MD
Jehan Z. Budak, MD
Associate Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington
Disclosures:
None

Lesson Plan

1Topic 1 Introduction

2Topic 2 Rationale for HIV Occupational PEP

3Topic 3 Risk Assessment of the Occupational Exposure Event

4Topic 4 Recommended Initial Steps Following An Exposure Event

5Topic 5 Recommended Antiretroviral Regimens for Occupational HIV PEP

6Topic 6 Obtaining Expert Consultation for Occupational HIV PEP

7Topic 7 Baseline Evaluation for Health Care Personnel and Source Patient

8Topic 8 Follow-Up of Health Care Worker After Exposure Event

9Topic 9 Summary Points

Lesson Quiz Occupational Postexposure Prophylaxis Quiz

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